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The next asbestos: Carbon nanotubes linked with mesothelioma in rodent study

Jennifer Sass

Posted May 20, 2008

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Multi-walled carbon nanotubes cause asbestos-like damage in test mice. That is what a new study is just out today in Nature Nanotechology is reporting, titled: Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study. The International Council on Nanotechnology (ICON), Rice University has posted an excellent scientific review of this and an earlier study with similar results. 

NRDC summarized the findings of five different research groups that since 2004 have reported that single-walled carbon nanotubes (SWCNTs) cause lung damage in test rodents, including dose-dependent rapid lung inflammation, rapid progressive fibrosis, and granulomas.

Carbon nanotubes are atom-thick sheets of graphite formed into cylinders. They may be formed from a single layer of graphite or they may consist of multiple concentric layers of graphite, resulting in multi-walled carbon nanotubes. They are estimated to be 100-times stronger and six-times lighter than steel, making them useful to strenthen building materials. Already they are found in many consumer products including super-strong tennis rackets, hockey sticks, racing bike frames, car parts, and golf clubs.

The ropelike filaments of carbon nanotubes are long, thin, and insoluble; these qualities are associated with the cancer-causing effects of asbestos and other deadly fibers.

In the trade press (Nanowerk), Donaldson is quoted as saying that, " "The results were clear ...Long, thin carbon nanotubes showed the same effects as long, thin asbestos fibers."

The website of the Woodrow Wilson Center Project on Emerging Nanotechnologies notes that "widespread exposure to asbestos has been described as the worst occupational health disaster in U.S. history and the cost of asbestos-related disease is expected to exceed $200 billion, according to major U.S. think tank RAND Corporation."

But, dollars don't tell the human toll. NRDC reports that in the United States, we still have more than one death per hour—approximately 10,000 per year—as a legacy from past and continuing exposure to asbestos. The global death rate is estimated to be 10 times higher.

Today's study authors report their results thus:  "Here we show that exposing the mesothelial lining of the body cavity of mice, as a surrogate for the mesothelial lining of the chest cavity, to long multiwalled carbon nanotubes results in asbestos-like, length-dependent, pathogenic behaviour. This includes inflammation and the formation of lesions known as granulomas. This is of considerable importance, because research and business communities continue to invest heavily in carbon nanotubes for a wide range of products under the assumption that they are no more hazardous than graphite. Our results suggest the need for further research and great caution before introducing such products into the market if long-term harm is to be avoided."

Recklessly exposing workers and the general population to deadly chemicals is neither humane nor civilized. Our society can do better this time around. Regulators must step in and prevent nanomaterials from being used in ways that may result in human exposure or environmental releases until they are safety tested and regulated.

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Kristen KulinowskiMay 20 2008 06:38 PM

Dear Jen,

Readers of your blog might be interested in viewing the Backgrounder that ICON has produced about this and a related paper published previously that also involved injection of MWCNT into mice abdomens.
We've summarized the works and interviewed several subject-matter experts from a variety of walks of life. We've also attempted to explain graphically the phagocytosis process that is believed to be important in understanding the effects of needle-like fibers.

hector picartMay 21 2008 12:36 PM

Has anyone talked to the bike racing companies, such as Trek or Cannondale to see if they have any of this matter on going?
This companies make bicycle racing frames.

David LashmoreMay 26 2008 09:43 AM

The authors have injected nanotubes with both nickel and cobalt catalysts into mice. For some reason, they did not remove these metals?

These metals are known to cause cancer. How can they distinguish between effects of nanotube geometry and the effects of nickel/cobalt on the tissue response.

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